BDBM50344962 (2S)-2-HYDROXYPENTANEDIOIC ACID::CHEMBL1615211::L-2-Hydroxyglutarate

SMILES O[C@@H](CCC(O)=O)C(O)=O

InChI Key InChIKey=HWXBTNAVRSUOJR-VKHMYHEASA-N

Data  1 KI  12 IC50

PDB links: 6 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50344962   

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50344962((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
Affinity DataIC50:  3.20E+5nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50344962((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed